Health Supplements / Life Extension / Life Extension Alpha-Lipoic Acid with Biotin 250mg 60 Capsules
Life Extension Alpha-Lipoic Acid with Biotin 250mg 60 Capsules
Life Extension Alpha-Lipoic Acid with Biotin 250mg 60 Capsules
Alpha-lipoic acid is an antioxidant used in Europe to promote liver and nerve health, and confer protective benefits against oxidative processes. Alpha-lipoic acid has been called the “universal” antioxidant because it boosts glutathione levels in cells already within a normal range and has potent antioxidant actions.128-130 Research has strongly implicated cellular oxidative damage caused by free radicals as a cause of many degenerative problems. What makes alpha-lipoic acid so effective as an antioxidant is its ability to quench free radicals in both aqueous and lipid environments. This means that the antioxidant activity of alpha-lipoic acid is working in the extra-cellular fluid and also within the cell. It also has metal chelating ability, helping the body rid itself of accumulated ingested toxins.131-134 Alpha-lipoic acid also is a cofactor for some of the key enzymes (alpha keto acid dehydrogenases) involved in generating energy from food and oxygen in mitochondria135-137 and thus plays a critical role in energy production within the cell’s mitochondria.127,135,136 One of the most beneficial effects of alpha-lipoic acid is its ability to regenerate other essential antioxidants such as vitamins C and E, coenzyme Q10, and glutathione, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). The evidence is especially strong for the ability of DHLA (dihydrolipoic acid, a reduced form of alpha-lipoic acid) to recycle vitamin E. This is apparently achieved directly by quenching tocopherol radicals or indirectly by reducing vitamin C or increasing the levels of ubiquinol (a derivative of CoQ10) and glutathione, that, in turn, helps regenerate tissue levels of vitamin E.135,138-144 In clinical studies to date with alpha-lipoic acid, there have been no reported serious adverse side effects, even at high doses. Among the mild, reversible side effects found in some patients have been allergic skin reactions and possible hypoglycemia in diabetics. Please note that the R-lipoic acid provides a more biologically active form of lipoic acid than alpha-lipoic acid at only a slightly higher cost. Supplement Facts Serving Size 1 capsule Amount Per Serving Biotin 2500 mcg Alpha-Lipoic Acid 250 mg Other ingredients: rice flour, gelatin, vegetable stearate. Non-GMO Dosage and Use Take one (1) capsule in the morning and one (1) capsule in the evening, preferably on an empty stomach, or as recommended by a healthcare practitioner. Caution If you are taking glucose lowering medication, consult your healthcare provider before taking this product. Warnings KEEP OUT OF REACH OF CHILDREN DO NOT EXCEED RECOMMENDED DOSE Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. References 1. Ann N Y Acad Sci. 2004 Jun;1019:406-11. 2. Postepy Biochem. 2008;54(2):129-41. 3. Ann N Y Acad Sci. 2002 Apr;959:491-507. 4. Chang Gung Med J. 2009 Mar-Apr;32(2):113-32. 5. Exp Biol Med (Maywood). 2007 May;232(5):592-606. 6. Curr Aging Sci. 2008 Mar;1(1):10-21. 7. Biochim Biophys Acta. 2000 Jun 26;1486(1):1-17. 8. Acta Physiol Scand. 2003 Aug;178(4):385-90. 9. Int J Sports Med. 1998 May;19(4):231-44. 10. 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