Health Supplements / Life Extension / Life Extension Melatonin 500 mcg 200 Vegetarian Capsules
Life Extension Melatonin 500 mcg 200 Vegetarian Capsules
Life Extension Melatonin 500 mcg 200 Vegetarian Capsules
Melatonin releases from the pineal gland, reaching its peak at night to help maintain healthy cell health throughout the body.82 Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified.83 Jet lag, shift work, and poor vision can disrupt melatonin cycles.84-86

Melatonin keeps our circadian cycle in tune.87,88 Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration.89-94 As melatonin diminishes with age, our biological functions are impaired.95,96 Melatonin also has strong antioxidant properties. It directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants.97 Melatonin is especially important for protecting cellular DNA against peroxynitrite damage by inhibiting peroxynitrite free radical reactions.98 Some research has found that melatonin increases the speed of falling asleep and adds to the quality of sleep in about 60% of people who use it.99-102

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving

Melatonin 500 mcg
Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule). Non-GMO

Dosage and Use

Take one (1) capsule 30 to 60 minutes before bedtime, or as recommended by a healthcare practitioner.
More may be taken if needed.

Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

Caution

Consult your healthcare provider before taking this product if you are being treated for a medical condition (especially autoimmune or depressive disorders). Use caution if combining with alcohol. This product is not intended for children, pregnant or lactating women, or women trying to become pregnant. Do not attempt to drive or operate heavy machinery after taking this product.

Warnings

  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged
References
  1. J Clin Endocrinol Metab. 1992 Oct;75(4):1002-4.
  2. J Clin Endocrinol Metab. 1997 Aug;82(8):2396-402.
  3. Clin Chim Acta. 2004 Mar;341(1-2):1-15.
  4. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1003-8.
  5. Maturitas.2010 Jun;66(2):172-9.
  6. Front Neuroendocrinol.2009 Jan;30(1):65-91.
  7. Biogerontology. 2008 Aug;9(4):235-46.
  8. Ann N Y Acad Sci. 2006 Nov;1088:139-52.
  9. Psychopharmacology (Berl). 2006 Nov;188(4):541-51.
  10. Pharmacol Ther. 2010 May;126(2):186-99. 
  11. Circulation. 2009 Sep 29;120(13):1231-40.
  12. Atherosclerosis. 2009 Sep;206(1):77-85. 
  13.  J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93.
  14. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4.
  15. Clin Chim Acta.2009 Oct;408(1-2):1-7. 
  16. J Endocrinol. 1999 Oct;163(1):1-5.
  17. Curr Ther Res. 2000;61(7):435-42.
  18. Arch Biochem Biophys. 1997 May 1;341(1):122-8.
  19. Curr Ther Res; 2002;63(4):263-72.
  20. J Nutr Biochem. 2007 Sep;18(9):629-34.
  21. Steroids. 2000 Mar;65(3):124-9.
  22. Steroids. 2009 Nov;74(12):931-7.
  23. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12308-12.
  24. Psychiatry Res. 2010 Jul 30;178(2):309-12. 
  25. Prog Brain Res. 2010;186:113-37. 
  26. Circ Res. 2010 May 14;106(9):1507-15. 
  27. CNS Neurosci Ther. 2010 Spring;16(1):32-44.
  28. Neuropsychopharmacology. 2009 Jul;34(8):1885-903. 
  29. Neurochem Int. 2008 Mar-Apr;52(4-5):522-40. 
  30. Psychoneuroendocrinology. 2008 Feb;33(2):214-26. 
  31. Eur J Med Chem. 2009 Jul;44(7):2944-51. 
  32. Horm Metab Res. 1998 Jan;30(1):16-28.
  33. J Clin Endocrinol Metab. 2002 Feb;87(2):589-98. 
  34. J Clin Endocrinol Metab. 2002 Aug;87(8):3632-9.
  35. Science. 1984 Sep 7:225(4666):1032-4.
  36. Altern Med Rev. 2007 Sep;12(3):280-4.
  37. Presented at the First International Congress on Ethnopharmacology, Strasbourg, France. 1990;June 5-9.
  38. Ethnopharmacology. 1995 Mar. Dr Waynberg.
  39. Eur J Cancer Prev. 2002;11(Suppl 2):S48-57.
  40. Br J Nutr. 2007 Aug;98(2):388-96.
  41. Cancer Causes Control. 2006 Mar;17(2):169-80.
  42. J Womens Health (Larchmt). 2010 Feb;19(2):209-18.
  43. J Alt Complement Med. 1998;4(3):289-303. 
  44. Menopause. 2008 Nov-Dec;15(6):1157-62. 
  45. Phytother Res. 2012 Apr;26(4):510-6.
  46. Phytomedicine. 2010 May;17(6):389-96.
  47. Maturitas. 2006 May 20;54(2):164-75.
  48. Udani J, Hardy M. The effect of HMRlignan on mammalian lignan and estrogen metabolite levels in post-menopausal women: A randomized, double-blind, single dummy, parallel group, pilot study. Nov 6, 2007.
  49. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):140-8.
  50. Am J Clin Nutr. 2010 Jul;92(1):141-53.
  51. Best Pract Res Clin Obstet Gynaecol. 2009 Feb;23(1):7-23. 
  52. Climacteric. 2009;12 Suppl 1:47-51. 
  53. J Sex Med. 2010 Jan;7(1 Pt 2):561-85. 
  54. Ann N Y Acad Sci. 2010 Aug;1204:179-87. 
  55. Sports Med. 2010 Jan 1;40(1):41-58. 
  56. Cell Mol Immunol. 2009 Aug;6(4):277-83.
  57. Med Pregl. 2009;62 Suppl 3:85-90.
  58. J Clin Endocrinol Metab. 2010 Aug;95(8):3569-77.
  59. Altern Ther Health Med. 2001 May-Jun;7(3):93-100.
  60. J Womens Health Gend Based Med. 2002 Mar;11(2):163-74.
  61. J Womens Health. 1998 Jun;7(5):525-9.
  62. J Steroid Biochem Mol Biol. 2004 Jul;91(3):147-55.
  63. Clin Cancer Res. 2007 Feb 1;13(3):1061-7.
  64. Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):339-44. 
  65. Cancer Causes Control. 2004 Oct;15(8):805-18. 
  66. Int J Cancer. 2004 Sep 1;111(3):440-3. 
  67. Int J Oncol. 2008 Oct;33(4):657-63. 
  68. Carcinogenesis. 2006 Apr;27(4):782-90.
  69. Food Chem Toxicol. 2008 Jul;46(7):2358-64.
  70. World Scientific, 1986:489-505.
  71. Maturitas. 2009 May 20;63(1):99-103. 
  72. Nat Prod Res. 2008 Apr 15;22(6):537-46. 
  73. Arzneimittelforschung. 1993 Jul;43(7):752-6. 
  74. Ceska Gynekol. 1998 Oct;63(5):388-92.
  75. J Agric Food Chem. 2006 Nov 15;54(23):8956-61.
  76. J Agric Food Chem. 2008 Feb 27; 56(4): 1415-22. 
  77. J Agric Food Chem. 2007 Nov 28;55(24):10050-4
  78. Nutr Res. 2008 Feb;28(2):72-7.
  79. Atherosclerosis. 2001 Sep;158(1):195-8.
  80. Clin Nutr. 2004 Jun;23(3):423-33.
  81. Exp Gerontol. 2001 Jul;36(7):1083-100.
  82. J Pineal Res. 1994 May;16(4):178-83.
  83. J Pineal Res. 2011 Jan;50(1):1-7.
  84. Bull Acad Natl Med. 2011 Oct;195(7):1527-46; discussion 1547-9.
  85. Curr Med Chem. 2012;19(21):3508-22.
  86. Free Radic Res. 2002 Dec;36(12):1323-9.
  87. J Endocrinol. 1981 Dec;91(3):467-75.
  88. Surg Today. 2003;33(12):896-901.
  89. J Oral Implantol. 2012 Apr 16. [Epub ahead of print]
  90. J Pineal Res. 2012 Oct;53(3):270-8.
  91. Recent Pat Endocr Metab Immune Drug Discov. 2011 May;5(2):100-8.
  92. J Physiol Pharmacol. 2011 Oct;62(5):521-6.
  93. J Pineal Res. 2012 Jan;52(1):62-70.
  94. Maturitas. 2002 Apr 15;41 Suppl 1:S85-104.
  95. Chronobiol Int. 2000 May;17(3):419-32.
  96. Aging (Milano). Oct1995;7(5):340-51.
  97. J Endocrinol Invest. 2006 Mar;29(3):281-7.
  98. Sleep. 1996 Jun;19(5):423-31.
  99. Clin Pharmacol Ther. 1995 May;57(5):552-8.
  100. Actas Esp Psiquiatr. 2000 Sep-Oct;28(5):325-9.
  101. J Clin Psychiatry. 2007 Feb;68(2):237-41.
  102. Available at: http://emedicine.medscape.com/article/126999-overview. Accessed March 21, 2013.
  103. Proc Soc Exp Biol Med. 1990 Apr;193(4):301-5.
  104.  J Sports Med Phys Fitness. 1989 Mar;29(1):52-6.
  105. J Strength Cond Res. 2010 Apr;24(4):1082-90.
  106. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. 
  107. Nutr Neurosci. 2003 Oct;6(5):269-75


Usual Price: S$24.90
Discount: 25% Off
Special Price: S$18.68