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Health Supplements / Life Extension / Life Extension Melatonin 6 Hour Timed Release 750 mcg 60 Vegetarian Tablets
Life Extension Melatonin 6 Hour Timed Release 750 mcg 60 Vegetarian Tablets
Life Extension Melatonin 6 Hour Timed Release 750 mcg 60 Vegetarian Tablets
Melatonin  releases  from  the  pineal  gland,  reaching  its  peak  at night  to help maintain healthy cell health  throughout  the body.82 Secretion  of  melatonin  declines  significantly  with  age,  as  the pineal  gland  becomes  calcified.83  Jet  lag,  shift  work,  and  poor vision can disrupt melatonin cycles.84-86 

Melatonin  keeps  our  circadian  cycle  in  tune.87,88 Not  only  does this hormone work to maintain cell health, it appears to regulate a system  of  self-repair  and  regeneration.89-94  As  melatonin diminishes  with  age,  our  biological  functions  are  impaired.95,96 Melatonin  also  has  strong  antioxidant  properties.  It  directly scavenges both hydroxyl and peroxyl free radicals, and it does so more  effectively  than  most  other  antioxidants.  It  also  greatly potentiates  the  efficiency  of  other  endogenous  and  exogenous antioxidants.97  Melatonin  is  especially  important  for  protecting cellular  DNA  against  peroxynitrite  damage  by  inhibiting peroxynitrite  free  radical  reactions.98 Some  research  has  found that melatonin  increases  the speed of  falling asleep and adds  to the quality of sleep in about 60% of people who use  it.99-102

Supplement Facts

Serving Size 1 vegetarian tablet
Servings Per Container 60

Amount Per Serving

Melatonin 750 mcg

Other ingredients: microcrystalline cellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, aqueous film coating (purified water, hydroxypropyl methylcellulose, glycerin), stearic acid, vegetable stearate, croscarmellose sodium, silica.

Dosage and Use

  • Take one tablet 30 to 60 minutes before bedtime, or as recommended by your healthcare practitioner. 
  • Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results. 
Caution
Consult your healthcare provider before taking this product if you are being treated for a medical condition (especially autoimmune or depressive disorders). Use caution if combining with alcohol. This product is not intended for children, pregnant or lactating women, or women trying to become pregnant. Do not attempt to drive or operate heavy machinery after taking this product. 

References
  1.  J Clin Endocrinol Metab. 1992 Oct;75(4):1002-4. 
  2.  J Clin Endocrinol Metab. 1997 Aug;82(8):2396-402. 
  3. Clin Chim Acta. 2004 Mar;341(1-2):1-15. 
  4. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1003-8. 
  5. Maturitas.2010 Jun;66(2):172-9. 
  6. Front Neuroendocrinol.2009 Jan;30(1):65-91. 
  7. Biogerontology. 2008 Aug;9(4):235-46. 
  8. Ann N Y Acad Sci. 2006 Nov;1088:139-52. 
  9. Psychopharmacology (Berl). 2006 Nov;188(4):541-51. 
  10. Pharmacol Ther. 2010 May;126(2):186-99. 
  11.  Circulation. 2009 Sep 29;120(13):1231-40 
  12. Atherosclerosis. 2009 Sep;206(1):77-85. 
  13. J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93 
  14. Clin Endocrinol (Oxf). 2006 Mar;64(3):260-4 
  15. Clin Chim Acta.2009 Oct;408(1-2):1-7. 
  16. J Endocrinol. 1999 Oct;163(1):1-5. 
  17. Curr Ther Res. 2000;61(7):435-42. 
  18. Arch Biochem Biophys. 1997 May 1;341(1):122-8. 
  19. Curr Ther Res; 2002;63(4):263-72 
  20. J Nutr Biochem. 2007 Sep;18(9):629-34. 
  21. Steroids. 2000 Mar;65(3):124-9. 
  22. Steroids. 2009 Nov;74(12):931-7. 
  23. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12308-12. 
  24. Psychiatry Res. 2010 Jul 30;178(2):309-12. 
  25. Prog Brain Res. 2010;186:113-37. 
  26. Circ Res. 2010 May 14;106(9):1507-15. 
  27. CNS Neurosci Ther. 2010 Spring;16(1):32-44. 
  28. Neuropsychopharmacology. 2009 Jul;34(8):1885-903. 
  29. Neurochem Int. 2008 Mar-Apr;52(4-5):522-40. 
  30. Psychoneuroendocrinology. 2008 Feb;33(2):214-26. 
  31. Eur J Med Chem. 2009 Jul;44(7):2944-51. 
  32. Horm Metab Res. 1998 Jan;30(1):16-28. 
  33. J Clin Endocrinol Metab. 2002 Feb;87(2):589-98. 
  34. J Clin Endocrinol Metab. 2002 Aug;87(8):3632-9. 
  35. Science. 1984 Sep 7:225(4666):1032-4. 
  36. Altern Med Rev. 2007 Sep;12(3):280-4 
  37. Presented at the First International Congress on Ethnopharmacology, Strasbourg,  France. 1990;June 5-9. 
  38. Ethnopharmacology. 1995 Mar. Dr Waynberg 
  39. Eur J Cancer Prev. 2002;11(Suppl 2):S48-57. 
  40. Br J Nutr. 2007 Aug;98(2):388-96. 
  41. Cancer Causes Control. 2006 Mar;17(2):169-80. 
  42. J Womens Health (Larchmt). 2010 Feb;19(2):209-18 
  43. J Alt Complement Med. 1998;4(3):289-303. 
  44. Menopause. 2008 Nov-Dec;15(6):1157-62. 
  45. Phytother Res. 2012 Apr;26(4):510-6 
  46. Phytomedicine. 2010 May;17(6):389-96. 
  47. Maturitas. 2006 May 20;54(2):164-75. 
  48. Udani J, Hardy M. The effect of HMRlignan on mammalian lignan and estrogen metabolite  levels in post-menopausal women: A randomized, double-blind, single dummy, parallel group, pilot study. Nov 6, 2007 
  49. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):140-8 
  50. Am J Clin Nutr. 2010 Jul;92(1):141-53. 
  51. Best Pract Res Clin Obstet Gynaecol. 2009 Feb;23(1):7-23. 
  52. Climacteric. 2009;12 Suppl 1:47-51. 
  53. J Sex Med. 2010 Jan;7(1 Pt 2):561-85. 
  54. Ann N Y Acad Sci. 2010 Aug;1204:179-87. 
  55. Sports Med. 2010 Jan 1;40(1):41-58. 
  56. Cell Mol Immunol. 2009 Aug;6(4):277-83. 
  57. Med Pregl. 2009;62 Suppl 3:85-90. 
  58. J Clin Endocrinol Metab. 2010 Aug;95(8):3569-77. 
  59. Altern Ther Health Med. 2001 May-Jun;7(3):93-100. 
  60. J Womens Health Gend Based Med. 2002 Mar;11(2):163-74. 
  61. J Womens Health. 1998 Jun;7(5):525-9. 
  62. J Steroid Biochem Mol Biol. 2004 Jul;91(3):147-55. 
  63. Clin Cancer Res. 2007 Feb 1;13(3):1061-7. 
  64. Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):339-44. 
  65. Cancer Causes Control. 2004 Oct;15(8):805-18. 
  66. Int J Cancer. 2004 Sep 1;111(3):440-3. 
  67. Int J Oncol. 2008 Oct;33(4):657-63. 
  68. Carcinogenesis. 2006 Apr;27(4):782-90. 
  69. Food Chem Toxicol. 2008 Jul;46(7):2358-64. 
  70. World Scientific, 1986:489-505. 
  71. Maturitas. 2009 May 20;63(1):99-103. 
  72. Nat Prod Res. 2008 Apr 15;22(6):537-46. 
  73. Arzneimittelforschung. 1993 Jul;43(7):752-6.  
  74. Ceska Gynekol. 1998 Oct;63(5):388-92. 
  75. J Agric Food Chem. 2006 Nov 15;54(23):8956-61. 
  76. J Agric Food Chem. 2008 Feb 27; 56(4): 1415-22. 
  77. J Agric Food Chem. 2007 Nov 28;55(24):10050-4 
  78. Nutr Res. 2008 Feb;28(2):72-7. 
  79. Atherosclerosis. 2001 Sep;158(1):195-8. 
  80. Clin Nutr. 2004 Jun;23(3):423-33 
  81. Exp Gerontol. 2001 Jul;36(7):1083-100. 
  82. J Pineal Res. 1994 May;16(4):178-83. 
  83. J Pineal Res. 2011 Jan;50(1):1-7. 
  84. Bull Acad Natl Med. 2011 Oct;195(7):1527-46; discussion 1547-9. 
  85. Curr Med Chem. 2012;19(21):3508-22. 
  86. Free Radic Res. 2002 Dec;36(12):1323-9. 
  87. J Endocrinol. 1981 Dec;91(3):467-75. 
  88. Surg Today. 2003;33(12):896-901. 
  89. J Oral Implantol. 2012 Apr 16. [Epub ahead of print] 
  90. J Pineal Res. 2012 Oct;53(3):270-8. 
  91. Recent Pat Endocr Metab Immune Drug Discov. 2011 May;5(2):100-8. 
  92. J Physiol Pharmacol. 2011 Oct;62(5):521-6. 
  93. J Pineal Res. 2012 Jan;52(1):62-70. 
  94. Maturitas. 2002 Apr 15;41 Suppl 1:S85-104. 
  95. Chronobiol Int. 2000 May;17(3):419-32. 
  96. Aging (Milano). Oct1995;7(5):340-51. 
  97. J Endocrinol Invest. 2006 Mar;29(3):281-7. 
  98. Sleep. 1996 Jun;19(5):423-31. 
  99. Clin Pharmacol Ther. 1995 May;57(5):552-8. 
  100. Actas Esp Psiquiatr. 2000 Sep-Oct;28(5):325-9. 
  101. J Clin Psychiatry. 2007 Feb;68(2):237-41. 
  102. Available at: http://emedicine.medscape.com/article/126999-overview. Accessed March 21,  2013 
  103. Proc Soc Exp Biol Med. 1990 Apr;193(4):301-5. 
  104. J Sports Med Phys Fitness. 1989 Mar;29(1):52-6. 
  105. J Strength Cond Res. 2010 Apr;24(4):1082-90. 
  106. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. 
  107. Nutr Neurosci. 2003 Oct;6(5):269-75. Page 3 of 4


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